Mrap2 | melanocortin 2 receptor accessory protein 2

GeneMGI:3609239

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Skeleton

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased bone mineral content	2 supporting datasets	Mrap2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.47x10^-21
increased circulating alkaline phosphatase level	1 supporting dataset	Mrap2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	7.42x10^-5
increased total body fat amount	2 supporting datasets	Mrap2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.21x10^-20
impaired glucose tolerance	1 supporting dataset	Mrap2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.22x10^-6
decreased lean body mass	2 supporting datasets	Mrap2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	7.94x10^-20
increased circulating calcium level	1 supporting dataset	Mrap2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.26x10^-5
increased red blood cell distribution width	1 supporting dataset	Mrap2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.15x10^-5
increased fasting circulating glucose level	1 supporting dataset	Mrap2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.4x10^-12
increased circulating insulin level	1 supporting dataset	Mrap2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.58x10^-134
abnormal bone structure	1 supporting dataset	Mrap2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.53x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mrap2.

Associated images

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Histopathology

There is no histopathology data found for Mrap2.

IMPC related publications

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External links

No external links available for Mrap2.

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*Mrap2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Mrap2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Mrap2^{tm42748(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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